Chung Kyu Kim Lee, M.D.
Yonsei University, College of Engineering and Science, Seoul, Korea, (1960)
Yonsei University College of Medicine, Seoul, Korea, M.D., (1965)
Post Graduate Education:
DePaul Hospital, Norfolk, Virginia (1965 - 66)
Therapeutic Radiology - Radiation Oncology,
University of Minnesota, Minneapolis, MN (1971 - 76)
Department of Radiology and Nuclear Medicine,
Yonsei University, College of Medicine,
Seoul, Korea (1968 - 71)
American Board of Radiology (June 1976)
Certified in Radiation Oncology (1976)
Korean Board of Radiology (1972)
American Board of Radiology (June 1976)
Minnesota State Board of Medical Examiners (1974)
Korean Board of Radiology (1972)
Korean Board of Medical Examiners (1965)
Certification for Special Procedures and Credentialing:
Stereotactic radiosurgery using linear accelerator (1992)
Stereotactic brain implantation using radioactive sources (1984)
Hyperthermia using Thermotron RF-8 for cancer treatment (1987)
Fractionated Radiosurgery (1993)
Certified for High Dose Rate Brachytherapy Treatment (1998)
Certified Beta-Cath System (9/7/2001)
Professor, Department of Therapeutic Radiology-Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN (1996-present)
Consultant, Veterans Administration Center, Department of Radiation Oncology, Minneapolis, MN (1994-present)
Associate Professor with Tenure, Department of Therapeutic Radiology - Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN (1986-1996)
Assistant Professor with Tenure, Department of Therapeutic Radiology - Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN (1976-1986)
Instructor, Severance Hospital, Yonsei Medical College, Seoul, Korea (1972-73)
Coordinator, Clinical Research and Clinical Data Base, Department of Therapeutic Radiology-Radiation Oncology Clinic University of Minnesota Medical School (1992-1999)
Acting Medical Director, During the absence of the Director on site, Fairview University Medical Center, Radiation Oncology Clinic (1997-May 1999)
Clinical Director, Department of Therapeutic Radiology- Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN (July 1992-1997)
American Association of University Women (AAUW)
American Association for Women Radiologists/Radiation Oncology Committee Member (AAWR) (1/2002 - )
American College of Radiology (ACR)
American College of Radiation Oncology (ACRO)
American Medical Association (AMA)
American Radium Society (ARS)
American Society of Clinical Oncology (ASCO)
American Society of Therapeutic Radiology & Oncology (ASTRO)
ASTRO CME Advisory Group (8/2001 - )
Cancer Center University of Minnesota, Full Member
Connections for Medical Students & Community Physicians, Mentor
European Society Therapeutic Radiology Oncology (ESTRO)
International Society of Hyperthermia
Minnesota Radiological Society
Minnesota State Medical Association
North American Hyperthermia Society (NAHS)
Radiation Research Society (RRS)
Radiological Society of North America (RSNA)
Ramsey County Medical Society
University of Minnesota Physicians (UMP)
University of Minnesota Committees:
Advisory Comm. for the University of Minnesota Cancer Center (1994-1997)
Biomedical Ethics Committee (1999-present)
Breast Cancer Advisory Committee (1999-present)
Breast Cancer Task Force (1993-1999)
Breast Cancer Surgeon Search Committee (March 2000-present)
Cancer Center Conference Education Committee (1993)
Cancer Center Data Base Quality Assurance Program Committee (1995-1998)
Clinical Associates Development Program Committee (1994-present)
Colleagues Editorial Board (1993-1996)
Education Committee, Department of Radiation Oncology
Gastrointestinal Cancer Program Committee (1998-present)
Geriatric Cancer Development Committee (1998)
Interdisciplinary Program for Pre-Post Radiation on Dental Care (1993-present)
Medical School Admissions Committee (1992-1996)
Multidisciplinary Program for Breast Cancer (1990-present)
Multidisciplinary Program for Colon-rectal Cancer (1990-present)
Multidisciplinary Program for Gastrointestinal Disease (1994-present)
Multidisciplinary Program for Head and Neck Cancer (1993-present)
Nominating Committee for Hospital Staff Council (1994)
Outpatient Quality Assurance Committee (1990-1995)
Pre-senate Committee (1994)
Prostrate Cancer Research Group (1998-present)
Respiratory Cancer Program Committee (1998-present)
Search Committee for Colorectal surgeon for University of Minnesota Medical School (1996)
Search Committee for Department Chairman University of Minnesota Medical School Dermatology (1995)
Search Committee for Department Chairman University of Minnesota Medical School of Neurology (1995)
Search Committee for Department Chairman University of Minnesota School of Orthopedics Surgeon (1997)
Search Committee for Department Chairman University of Minnesota Medical School of Urology (1996)
Search Committee for Tickle Chair of the Cancer Center (1998)
Therapeutic Radiology-Radiation Oncology Post Tenure Review Committee (1999-present)
UMP Compliance Officer for Radiation Oncology (1999-present)
University of Minnesota Medical School Promotion and Tenure Committee (1998-2001)
National and International Committees:
AAWR Radiation Oncology Committee (1994-present)
ABR Radiation Oncology Certification Examination Program (1997-present)
American College of Radiology Oral Board Examiners (1995)
American Radium Society 1999-2000 Scientific Program Committee
American Society of Radiation Oncologists
ASTRO: Education Committee (1995-1997)
CALGB: Principal Investigator University of Minnesota Radiation Oncology (1985-present)
ECOG: Principal Investigator Radiation Therapy on Head and Neck Protocols University of Minnesota (1992-present)
Oncology Practice Accreditation Program
Program Committee for International Congress Hyperthermia for 2000
Radiation Therapy Oncology Group (RTOG)
RSNA-Scientific Exhibits Committee for 2000
RSNA-Chairman Scientific Exhibition Radiation Oncology Subcommittee (1999-present)
RTOG: Principal Investigator University of Minnesota (1987-1998)
Regional Study Chair for Amersham Strontium 89 Protocol (1989-1994)
RTOG: Late Effects Sub Committee (1994-preesent)
Thermotron Hyperthermia Research Group: National (1990-1995); International (1987-present)
American Cancer Society of Minnesota
Colorectal Cancer Program Committee in Twin Cities (1998)
Connections for Medical Students & Community Physicians, Mentor (2001)
Fairview Southdale Medical Education Committee (2000-2001)
Hennepin County Education Program Committee (1999-present)
Scientific Peer Review and Editorial Support:
American Journal of Clinical Oncology (ad hoc)
Technology Assessment of ICSI Institute for Clinical Systems Integration (1995, 1996)
United Sates Army Medical Research and Material Command (USAMRMC) Prostate Cancer Research Program (PCRP) 1997, 1998, 1999
Formal Courses of Instruction
TRad 5510 Radiation Oncology Clinical Research
TRad 5511 Outpatient diagnosis, evaluation and treatment of adults and children with cancer
TRad 7505 Externship in Radiation Oncology
TRad 7507 Advanced Externship in Radiation Oncology
Student Research Advisory:
Jacklyn Tran Nguyen, Diagnosis of Hodgkin's Disease (1990-91)
Christina Freschette, Medical Student, Research Project on Bone Marrow Transplantation on Hodgkin's Disease (1997, 1999)
Lisa Siskind, Doctoral Candidate, Consultant for Clinical Aspect Dr. Higgins, Primary Academic Advisor for Ph.D. project "Modeling Normal Tissue Response to Radiation Therapy for Heart and Lung" (1997-1999)
Minnesota Medical Foundation Special Grant for Breast Cancer Research- $28,000
Amersham International protocol #Pr97HL03 Phase II study of 99mTc-HL Spect imaging to detect tumor hypoxia, predict radio-resistance, and establish safety and tolerability inpatients with newly-diagnosed squamous cell carcinoma of the head and neck -$8,500
Principal Investigator in Clinical Research:
CALGB: Radiation Therapy Co-chair on protocols: 9192, 9051, 8783
Hyperthermia Protocol #1- A phase I/II study, definitive radiotherapy and hyperthermia in patients with advanced head and neck, breast or soft tissue or other superficial or sub surface tumors suitable for definitive radiotherapy. (1989-1995)
Hyperthermia Protocol #2- A phase I/II study, combination of radiotherapy and Thermotron RF Model 8 hyperthermia in patients with deep-seated malignant tumors. (1989-1995)
Hyperthermia Protocol #3- A phase I/II research study using irradiation combined with hyperthermia produced by the Thermotron RF Model 8 for treatment of localized chest wall recurrence of breast carcinoma. (1989-1995)
Hyperthermia before vs. after radiotherapy in patients with advanced superficial and sub surface tumors suitable for definitive or palliative radiotherapy (Protocol UMHT 9601)- Open
A phase III randomized study of irradiation combined with once or twice a week hyperthermia using the Thermotron RF Model 8 for localized chest wall recurrence of breast cancer (Protocol UMHT 9602)- Open
Pilot study on combination of radiotherapy and Thermotron RF Model 8 hyperthermia in patients with deep-seated malignant tumors (Protocol UMHT 9603)- Open
Treatment of Bone Metastasis using Systemic Radioactive Agent-Strontium 89- Amersham Study (1995)
Karolinske Institute, Stockholm, Sweden. Special consulting faculty for the evaluation of Cardiac complication relative to volume of radiated heart in Hodgkin's Disease patients. (1994)
Fractionated stereotactic radiosurgery for intracranial skull based tumors. (1993-present)
Primed peripheral blood stem cell autologous transplantation for Lymphoma and Hodgkin's Disease. (1993-1995; 1995-present)
High dose chemotherapy with autologous bone marrow, and peripheral blood stem cell rescue for patients with chemotherapy responsive advanced breast cancer. (1993-1995; 1995-present)
Long term cardiac complication relative to radiated heart volume in Hodgkin's Disease after mantle treatment in collaboration with Kalolinski Institute, Stockholm, Sweden. (1994-1999)
Radiotherapy consultation for Non-Hodgkin's Lymphoma and Hodgkin's disease auto-transplant recipients.
Developing Research Program as Principal Investigator:
Evaluation of radiation mucositis using Amofostine for head and neck cancer.
Reduction of mucositis using Pilocarpine prior and during radiotherapy.
Stereotactic radiosurgery for head and neck cancer.
MRI angiography for coronary and carotid vascular changes in post radiation therapy for Hodgkin's disease.
Pilot study on chemo-radiation on head and neck cancer using infusional Taxol and Herceptine.
Amersham International protocol #Pr97HL03
Prevention of vascular restenosis (coronary and peripheral vessels) using radiation therapy.
Treatment of biliary tree, prostate and other cancers using High dose rate, Vari Source, Varian Co.
Intraoperative use of electron treatment using Mobetrom
Phase II study for head and neck cancer using infusional Taxol and altered fractionation radiation.
A double Blind Randomized, Vehicle-Controlled Study Comparing the Safety and Efficacy of Benzydamine Hydrochloride 0.15% Oral Rinse Including A Ssperate Open-Label Standard of Care Arm in Subjects with Radiation Induced Oral Mucositis
RTOG Protocol P-0011 Phase III Randomized Study of Adjuvant Therapy for High Risk PT2-3 No Prostate Cancer
RTOG Protocol 9910 - A Phase III Trial to Evaluate the Duration of Total Androgen Suppression (TAS) and Radiation Therapy (RT) in Intermediate Risk Prostate Cancer
RTOG Protocol 99-02 A Phase III Protocol of Androgen Suppression (AS) and Radiation Therapy (RT) vs AS and RT Followed by Chemotherapy with Paclitaxel, Estramustine, and Etoposide (TEE) for Localized, High-Risk, Prostate Cancer.
Clinical Research Interest:
MRI angiography for coronary and carotid vascular changes in post radiation therapy for Hodgkin's disease
Breast Carcinoma, conservation surgery and radiation therapy
Bone Marrow Transplantation for Recurrent Hodgkin's Disease and non-Hodgkin's Lymphoma
Bone Marrow Transplantation for Breast Cancer
Head and Neck Cancer
Hyperthermia using Thermotron RF-8
Intraluminal brachytherapy (low-dose rate) for cancer of biliary tract
Stereotactic interstitial brachytherapy for brain tumors
Stereotactic Radiosurgery for skull base, head and neck tumors
On-line imaging & Quality Assurance
3-D Treatment planning
Second malignant neoplasm, long term survivors after radiation therapy
Measurement of tumor PO2 & response of tumor using soft tissue sarcoma, bulky Head & Neck cancer, and hyperthermia patients
I have a major interest in the improvement of recurrence-free survival of surgically staged, early-stage Hodgkin's disease patients treated with curative radiotherapy and am considered an expert in this area nationally and internationally. I have been the co-chair in three clinical trials- CALGB 9192, 9051, and 8783 and was a member of the International Hodgkin's Disease Task Force in 1989, in Paris, France. Research from the Department of Therapeutic Radiology - Radiation Oncology at the University of Minnesota has been most informative in the treatment of Hodgkin's disease. In particular, our success in the application of low-dose lung irradiation for Hodgkin's patients with large mediastinal masses and low-dose liver irradiation for stage IIIA, spleen-positive patients have been of major interest in the medical community worldwide.
In addition, I am evaluating on an ongoing basis the treatment results of Hodgkin's patients treated over the last 20 years at the University of Minnesota Hospital and Clinic, also studying various complications and side effects in surgically-staged Hodgkin's patients initially treated with curative radiotherapy during this period. Effects on pulmonary, thyroid, cardiac, reproductive, vascular and intestinal organs (including the liver) are being examined, in addition to the incidence of a second neoplasm.
I have developed the MT ratio for a more uniform, mathematically derived method of measuring mediastinal mass for the improved evaluation and treatment of Hodgkin's disease patients, which has been used worldwide in protocols and clinical studies.
Currently, we are studying long-term complication of radiation therapy in Hodgkin's patients. This is an international collaboration with the Kalolinski Institute, Stockholm, Sweden. The long-term cardiac complication relative to radiated heart volume after mantle radiation is in the process of being evaluated.
Developing a protocol in conjunction with the Department of Radiology to detect long-term changes of the cardiovascular system using MRI is going to be a very important study. The program has been collaborated with the Kalolinski Institute, Stockholm, Sweden.
A new phase III protocol of poor risk, early stage Hodgkin's disease is being developed in CALGB group and I am co-chair of radiation oncology. Result of bone marrow transplantation for Hodgkin's Disease.
The curative treatment of non-Hodgkin's lymphoma is a perplexing area of modern medicine. I am studying the effectiveness of curative radiotherapy for surgical-staged, early non-Hodgkin's lymphomas on an ongoing basis. Our impressive results, especially with histiocytic lymphoma, represent a major source of data relating to the management of non-Hodgkin's lymphoma. This data is an important part of a limited amount of information available on Non-Hodgkin's lymphoma nationally and internationally. Result of bone marrow transplantation for Non-Hodgkin's Lymphoma.
Conservation surgery and radiation therapy in the management of early stage breast carcinoma (instead of extensive radical surgery) has been a major breakthrough during the last decade. Radiation therapy techniques can be very complex. With the cooperation of the Physics Section of the Department of Therapeutic Radiology - Radiation Oncology at UMHC, new and improved treatment techniques have been developed. The University of Minnesota experience is being evaluated and a database has been set up.
I am a member of the multidisciplinary program of Breast Cancer at the University of Minnesota Cancer Center.
Improvement of radiation for breast cancer treatment using IMRT.
Bone Marrow Transplantation
Advanced and recurrent Hodgkin's disease, non-Hodgkin's lymphoma and breast cancer have been studied in conjunction with hematology and medical oncology departments, as a co-investigator. Hodgkin's Disease result has been summarized.
Head and Neck Cancer
Multidisciplinary program of Head and Neck Cancer is actively functioning to collaborate the treatment program. We are participating in group studies in RTOG and ECOG.
Measurement of Tumor O2 and response of tumor: Partial pressure of Oxygen (pO2) within the tumor is an important predictor of their sensitivity to radiotherapy as well as chemotherapy. Tumor pO2 will be measured by using polarographic needle electrode. Association between pO2 level of tumor and response will be studied. Miscellaneous information will be used for future development of treatment program.
Glutamine vs. Glycine Nutritional Supplementation during Radiation Therapy to evaluate effectiveness of preventing mucositis by Glutamine. Target population is going to be patients with Head and Neck Cancer, and patients who receive abdominal irradiation.
Infusional chemotherapy in conjunction with radiation therapy is being developed currently.
Amofostine to reduce mucositis and xyleslomia.
Development of treatment medication by Herception status.
By using the Thermotron RF-8 to deliver hyperthermia in conjunction with radiation therapy, we have had improved treatment results for some patients with tumors that are difficult to control with conventional treatment. Results for both superficial as well as deep-seated tumors have been reported. Currently three phase I/II protocols are being studied and three additional phase III protocols are in the developmental stage.
I have spoken and presented data nationally and internationally on hyperthermia and am respected as an authority. Our institution is the only resource of hyperthermia treatment in the Twin City Metropolitan area, as well as in the surrounding states.
Brain Tumor - Stereotactic Interstitial Brachytherapy
The management of brain tumors has been a most difficult area with conventional approaches, especially in tumors that are unrespectable, recurrent, histiologically poor, etc. I have developed a program of brain tumor implantation using Iridium 192 for a selected group of patients together with Dr. Maxell of the Neurosurgery Department. Since that breakthrough, we have expanded our program to be cutting edge in the treatment of brain tumors using high-dose stereotactic radiosurgery and fractionated radiosurgery. I am co-investigator of this program at the University of Minnesota. Long term results are being evaluated after stereotactic interstitial brachytherapy.
Intraluminal brachytherapy in addition to external beam irradiation has been developed in collaboration with the Invasive Radiology Department at the University of Minnesota. I am working as a multidisciplinary member of the upper and lower Gastro-intestinal cancer group, including Colo-rectal cancer.
A Strontium Chloride treatment study has been initiated at the University of Minnesota Hospital and other areas of the upper Midwest in conjunction with Amersham Corporation. We are using Strontium 89 to treat bone metastases as well as breast, prostate and lung cancers.
Listed in The Best Doctors in the Twin Cities by Kare 11 for the Department of Radiation Oncology 1999.
Honored as one of the top 4% of all doctors in the United States as "The Best in America" for the year 2000.