George J. Trachte, PhD

Interim Department Chair of Biomedical Sciences, Medical School, Duluth Campus

George J. Trachte

Contact Info

gtracht1@d.umn.edu

Office Phone 218-726-8975

Fax 218-726-7906

Office Address:
Department of Biomedical Sciences
319 SMed
1035 University Dr
Duluth, MN 55812

Interim Department Chair of Biomedical Sciences, Medical School, Duluth Campus

Professor, Department of Biomedical Sciences


PhD, Thomas Jefferson University (Physiology), 1979

BS, Pennsylvania State University (Biology), 1975

Research

Research Summary/Interests

Natriuretic peptides and their influences on the nervous system with emphasis on interactions with the sympathetic nervous system and hearing.

Publications

See full list of publications at: PubMed

1. Trachte, G.J and Fitzakerley, JL: Natriuretic peptides modulate inner ear functions. Submitted to Physiological Genomics 2017

2. Hinz, M, Stein, A Trachte, G.J. and Uncini, T: Neurotransmitter testing: a comprehensive. Neurophychiatr Dis Treat: 2010 (2): 177-183, 2010

3. Trachte G.J., Uncini T., and Hinz M.: Both stimulatory and inhibitory effects of dietary 5-hydroxytryptophan and tyrosine are found on urinary excretion of serotonin and dopamine in a large human population. Neuropsychiatr Dis Treat 5:227-35 (Epub 2009 May 20)

4. Trachte, G.J., Neuronal Regulation and Function of Natriuretic Peptide Receptor C. Peptides 26: 1060-1067, 2005.

5. Trachte, G.J.: Natriuretic peptides suppress protein kinase C activity to reduce evoked dopamine efflux from Pheochromocytoma (PC12) cells. Endocrinology 144: 94-100, 2003.

6. Trachte, G.J.: Natriurectic peptide clearance receptors are critical regulators of sympathetic neurotransmission. Recent Res Devel. Endocrinol 2:173-182, 2001

7. Trachte, G.J.: Signal-transducing activity of natriuretic peptide C receptor (NPR-C) in neural tissue. pp. 436-444 In "Pharmacology and Therapeutics in the new millennium" ed. By SK Gupta, Narosa Publishing House, New Delhi, India, 2001

8. Trachte, G.J.: Urodilatin attenuates sympathetic neurotransmission in the rabbit isolated vas deferens without activating guanylyl cyclase. Life Sciences69: 2833-2844, 2001.

9. Trachte, G.J.: Depletion of natriuretic peptide C receptors eliminates inhibitory effects of C-type natriuretic peptide on evoked neurotransmitter efflux. J. Pharmacol. Exp. Ther.294: 210-215, 2000.

10. Kanwal, S., D.G. Lowe and G.J. Trachte: Intracellular fragments of the natriuretic peptide receptor-C (NPR-C) attenuate dopamine efflux. Endocrinology140: 1118-1124, 1999.

11. Takida, S., B.J. Elmquist and G.J. Trachte: C-type natriruetic peptide attenuates evoked dopamine efflux by influencing GoalphaHypertension33: 124-129, 1999.

12. Takida, S and Trachte G.J.: Signal transducing role of clearance receptors as exemplified by the natriuretic peptide C receptor. Current Topics in Pharamcology 4: 97-106, 1998

13. Trachte, G.J.: "Physiology of the clearance receptor" in "Contemporary Endocrinology: natriuretic peptides in health and disease" pp. 259-274 ed. by WK Samson and ER Levin Humana Press Inc, Totowa, NJ 1997

14. Kanwal, S., B.J. Elmquist and G.J. Trachte: Atrial natriuretic peptide inhibits evoked catecholamine release by altering sensitivity to calcium. J. Pharmacol. Exp. Ther.283: 426-433, 1997.

15. Trachte, G.J., S. Kanwal, B.J. Elmquist and R.J. Ziegler: C-type natriuretic peptide neuromodulates via "clearance" receptors. Amer. J. Physiol., 268: C978-C984, 1995.

16. Trachte, G.J. and J.G. Drewett: C-type natriuretic peptide neuromodulates independently of guanylyl cyclase activation. Hypertension23: 38-43, 1994.

17. Kanwal, S. and G.J. Trachte: Potassium channel inhibitors attenuate neuromodulatory effects of atrial natriuretic factor in the rabbit isolated vas deferens. J. Pharmacol. Exp. Ther.268: 117-123, 1994.

18. Trachte, G.J.: Atrial natriuretic factor (ANF) alters neurotransmission independently of Guanylate cyclase-coupled receptors in the rabbit vas deferens. J. Pharmacol. Exp. Ther.264: 1227-1233, 1993.

19. Drewett, J.G., R.J. Ziegler and G.J. Trachte: Neuromodulatory effects of atrial natriuretic peptides correlate with an inhibition of adenylate cyclase but not an activation of guanylate cyclase. J. Pharmacol. Exp. Ther.260: 689-696, 1992.

20. Johnson, B.G., G.J. Trachte and J.G. Drewett: Neuromodulatory effect of the atrial natriuretic factor clearance receptor binding peptide, C-ANF(4-23)-NH2 in rabbit isolated vasa deferentia. J. Pharmacol. Exp. Ther.257:720-726, 1991.

21. Waters, D.J., D.D. Caywood, G.J. Trachte, R.T. Turner and S.F. Hodgson. The effect of aspirin on bone mass and bone prostaglandin E in canine immobilization (disuse) osteoporosis. Acta Orthopaedica Scandinavica 62:238-243, 1991.

22. Fitzgerald, T.J., M.A. Tomai, G.J. Trachte and T. Rice: Prostaglandins in experimental syphilis: treponemes stimulate adherent spleen cells to secrete prostaglandin E2, and indomethacin upregulates immune functions. Infection and Immunity 59:143-149, 1991.

23. Odean, M.J., G.J. Trachte and A.G. Johnson. Characterization of immune suppression induced by polyribonucleotides. Int. J. Immunopharmacology13:339-348, 1991.

24. Trachte, G.J., C.M. Ferrario and M.C. Khosla: Selective blockade of angiotensin responses in the rabbit isolated vas deferens by angiotensin receptor antagonists. J. Pharmacol. Exp. Ther.255:929-934, 1990.

25. Drewett, J.G., R.J. Ziegler and G.J. Trachte. Neuromodulatory effects of ANF are independent of guanylate cyclase in adrenergic, neuronal pheochromocytoma cells. J. Pharmacol. Exp. Ther.255:497-503, 1990.

26. Trachte, G.J.: Pharmacological differentiation of angiotensin effects in the rabbit isolated vas deferens with dithiothreitol and pertussis toxin. J. Pharmacol. Exp. Ther.253:80-84, 1990.

27. Trachte, G.J. and L.J. Heller: Adenosine receptor antagonism attenuates angiotensin II effects on adrenergic neurotransmission in the rabbit isolated vas deferens. J. Pharmacol. Exp. Ther.253:490-496, 1990.

28. Trachte, G.J., K. Meixner, C.M. Ferrario and M.C. Khosla: Prostaglandin production in response to angiotensin-(1-7) in rabbit isolated vas deferens. Prostaglandins39:385-394, 1990.

29. Stein, E. and G.J. Trachte. Thromboxane mimetics enhance adrenergic neurotransmission in the rabbit isolated portal vein. J. Cardiovasc. Pharmacol.14:469-474, 1989.

30. Heller, L.J., G.J. Trachte and J.F. Regal. Role of adenosine in hypoxic alterations of anaphylaxis of isolated guinea pig hearts. Amer. J. Physiol. 257:H1378-1388, 1989.

31. Drewett, J.G., R.J. Ziegler, G.R. Marchand and G.J. Trachte. Cyclic guanosine 3',5' monophosphate mediates the inhibitory effect of atrial natriuretic factor in adrenergic, neuronal pheochromocytoma cells. J. Pharmacol. Exp. Ther.250:428-432, 1989.

32. Trachte, G.J. and E. A. Stein. Thromboxane receptor agonists enhance adrenergic neurotransmission in rabbit isolated mesenteric arteries. J. Pharmacol. Exp. Ther.249:216-220, 1989.

33. Drewett, J.G., G.R. Marchand and G.J. Trachte. Atrial natriuretic factor inhibits adrenergic neurotransmission in rabbit isolated portal veins. American Society of Hypertension Symposium Series, Vol. 3, Advances in Atrial Peptide Research, p. 342-351, 1989.

34. Drewett, J.G., G.J. Trachte and G.R. Marchand. Atrial natriuretic factor inhibits adrenergic and purinergic neurotransmission in the rabbit isolated vas deferens. J. Pharmacol. Exp. Ther.248:135-142, 1989.

35. Trachte, G.J., S.B. Binder and M.J. Peach. Indirect evidence for separate vesicular neuronal origins of norepinephrine and ATP in the rabbit vas deferens. Eur. J. Pharmacol.164:425-433, 1989.

36. Trachte, G.J. Angiotensin effects on vas deferens adrenergic and purinergic neurotransmission. Eur. J. Pharmacol.146:261-269, 1988.

37. Trachte, G.J., P.J. Hook, J.R. Kemp, E.P. Acosta, and R.J. Ziegler. Thromboxane synthesis and actions in isolated adrenergic nerve (PC12) cells. J. Pharmacol. Exp. Ther.247:43-46, 1988.32. Trachte, G.J. Adrenergic nerves mediate angiotensin-induced prostaglandin release in the rabbit vas deferens. J. Pharmacol. Exp. Ther.246:211-217, 1988.

38. Drewett, J.G., G.R. Marchand, R.J. Ziegler and G.J. Trachte. Atrial natriuretic factor inhibits norepinephrine release from an adrenergic clonal cell line (PC12). Eur. J. Pharmacol.150:175-179, 1988.

39. Trachte, G.J. Prostaglandins do not mediate the inhibitory effects of angiotensins II and III on autonomic neurotransmission in the rabbit vas deferens. Prostaglandins36:215-228, 1988.

40. Trachte, G.J. and E. Stein. Platelet-generated thromboxane A2 enhances norepinephrine release from adrenergic nerves. J. Pharmacol. Exp. Ther. 247:1139-1145, 1988

41. Trachte, G.J., E. Stein, and M.J. Peach. Alpha adrenergic receptors mediate angiotensin-induced prostaglandin production in the rabbit isolated vas deferens. J. Pharmacol. and Exp. Ther.240:433-440, 1987.

42. Trachte, G.J. Adrenergic receptors mediating force and prostaglandin production in the rabbit vas deferens. Prostaglandins 33:25-35, 1987.

43. Trachte, G.J. Prostacyclin mediates arachidonic acid-induced relaxation of rabbit isolated mesenteric arteries. J. Cardiovasc. Pharmacol.8:758-764, 1986.

44. Trachte, G.J. A thromboxane agonist (U46619) potentiates norepinephrine efflux from adrenergic nerves. J. Pharmacol. and Exp. Ther.237:473-477, 1986.

45. Saye, J., S.B. Binder, G.J. Trachte and M.J. Peach. Angiotensin peptides and PGE2 synthesis: modulation of neurogenic responses in the rabbit vas deferens. Endocrinology119:1895-1903, 1986

46. Trachte, G.J. The influence of prostaglandins on neurotransmission in the rabbit isolated vas deferens. Prostaglandins29:47-60, 1985.

47. Baker, K.M., C.P. Campanile, G.J. Trachte and M.J. Peach. Identification and characterization of the rabbit angiotensin II myocardial receptor. Circ. Res.54:286-295, 1984.

48. Trachte, G.J., E.J. Sybertz, M. Michener, S. Bruce Binder and M.J. Peach. angiotensin III induced modulation of neurogenic responses in the rabbit vas deferens and portal vein. Naunyn Schmiedebergs Arch. Pharmacol. 326:327-333, 1984.

49. Trachte, G.J. and M.J. Peach. Temperature effects on octa- and hepta-peptide angiotensins. Proc. Soc. Exp. Biol. Med.177:47-54, 1984.

50. Trachte, G.J. and M.J. Peach. A potent nonequilibrium angiotensin II antagonist induces only competitive inhibition of angiotensin III responses. J. Cardiovasc. Pharmacol.5:1025-1033, 1983.

51. Trachte, G.J., J.A. Ackerly and M.J. Peach. Inotropic cardiac and vascular actions of (Ala7) angiotensin analogs. J. Cardiovascular Pharmacol.3:138-146, 1981.

52. Trachte, G.J. and A.M. Lefer. Prostaglandin-mediated vasoconstriction in isolated cat arteries. Blood Vessels 17:196-201, 1980.48. Feinberg, G., G.J. Trachte, M. Curtis, and A.M. Lefer. Dietary modification of the vascular effect of prostacyclin in hypertensive rats. Prostaglandins and Med.5:235-242, 1980.

53. Trachte, G.J. and A.M. Lefer. Shock potentiating actions of angiotensin II infusion in cats. Circ. Shock7:343-351, 1980.

54. Trachte, G.J. and A.M. Lefer. Effect of angiotensin II receptor blockade by (Sar1, Ala8) angiotensin II (saralasin) in hemorrhagic shock. Amer. J. Physiol.236:H280-H285, 1979.

55. Lefer, A.M., G.J. Trachte, J.B. Smith, W.E. Barnette, and K.C. Nicalaou. Circulatory and platelet actions of 6,9-thio-prostacyclin (PGI2-S) in the cat. Life Sci.25:259-264, 1979.

56. Trachte, G.J., and A.M. Lefer. Mechanism of the protective action of the converting enzyme inhibitor (SQ 14,225) in hemorrhagic shock. Proc. Soc. Exp. Biol. Med.162:54-57, 1979.

57. Trachte, G.J. and A.M. Lefer. Inotropic and vasoactive effects of the naturally occurring angiotensins in isolated cat cardiac muscle and coronary arteries. Res. Comm. Chem. Pathol. Pharmacol.25:419-427, 1979.

58. Trachte, G.J., A.M. Lefer, D. Aharony, and J.B. Smith. Potent constriction of cat coronary arteries by hydroperoxides of arachidonic acid and its blockade by anti-inflammatory agents. Prostaglandins19:909-914, 1979.

59. Trachte, G.J., and A.M. Lefer. Salutary effects of dexamethasone in hemorrhagic shock. Arch. Internat. Pharmacodyn. Therap.232:309-320, 1978.

60. Trachte, G.J., and A.M. Lefer. Beneficial action of a new angiotensin converting enzyme inhibitor (SQ 14,225) in hemorrhagic shock in cats. Circ. Res.43:577-582, 1978.

61. Trachte, G.J., and A.M. Lefer. Influence of dopamine on liver dynamics in hemorrhagic shock. Circ. Shock4:305-317, 1977.

Teaching

Teaching Areas

  • Former Course Director for Cardiovascular Renal & Respiratory Medicine (2011-2017)
  • Teach Autonomic Pharmacology in the following Medicine Blocks: Neuroscience; Musculoskeletal system; Respiratory; Cardiovascular; and Renal. 
  • Participate in Problem Based Learning cases in Neurological, Cardiovascular & Respiratory Medicine, Renal and Electrolytes, and Immunology/Hematology/Oncology courses.  
  • Course Director and Instructor for the undergraduate/graduate course Biomedical Sciences 5001 (Introduction to Pharmacology).
  • Teach muscle, skin and respiratory physiology to medical students.
  • Teach fluid compartments, skin, gastrointestinal, renal and respiratory physiology to graduate/undergraduates.

Mentoring/Advising: undergraduate & medical students.