Christopher Honda, PhD

Professor Emeritus, Department of Neuroscience

Professor Emeritus, Department of Neuroscience


Research

Research Summary/Interests

Peripheral mechanisms of nociception

The skin and deep tissues comprise a vital interface between our bodies and our surroundings. The senses of touch and pain are especially critical in interactions with our environment. Our research interests are centered on functional and structural mechanisms underlying these senses, and there is a particular emphasis in our laboratory on neuronal mechanisms contributing to the sensory experience of pain. 

We use anatomical, immunoistochemical, and electro-physiological techniques to establish relationships between neuronal structure, chemistry and function. We apply these approaches to the study of individual sensory neurons of the peripheral nervous system. Our ain research direction is the functional regulation of peripheral opioid receptors, and how these receptors contribute to peripheral analgesic systems.

Publications

Skorput, AGJ, Zhang, X, Waataja, JJ, Peterson, CD, Riedl, MS, Kitto, KF, Truong, H, Huffman, C, Salton, SR, Fairbanks, CA, Honda, CN & Vulchanova L 2018, ‘Involvement of the VGF-derived peptide TLQP-62 in nerve injury-induced hypersensitivity and spinal neuroplasticity’ Pain, vol. 159, no. 9, pp. 1802-1813. https://doi.org/10.1097/j.pain.0000000000001277

Doolen, S, Cook, J, Riedl, M, Kitto, K, Kohsaka, S, Honda, CN, Fairbanks, CA, Taylor, BK, Vulchanova, L. 2017, ‘Complement 3a receptor in dorsal horn microglia mediates pronociceptive neuropeptide signaling’ Glia, vol. 65, no. 12, pp. 1976-1989. https://doi.org/10.1002/glia.23208

Kashem, SW, Riedl, MS, Yao, C, Honda, CN, Vulchanova, L & Kaplan, DH 2015, ‘Nociceptive Sensory Fibers Drive Interleukin-23 Production from CD301b+ Dermal Dendritic Cells and Drive Protective Cutaneous Immunity’ Immunity, vol. 43, no. 3, pp. 515-26. https://doi.org/10.1016/j.immuni.2015.08.016 Erratum in: Immunity. 2015, Oct 20, vol. 43, no. 4, pp. 830.

Brederson, JD & Honda, CN 2015, ‘Primary afferent neurons express functional delta opioid receptors in inflamed skin’ Brain Res, vol. 1614, pp. 105-11. https://doi.org/10.1016/j.brainres.2015.04.023

Abdelhamid, RE, Kovács, KJ, Honda, CN, Nunez, MG & Larson, AA 2013, ‘Resiniferatoxin (RTX) causes a uniquely protracted musculoskeletal hyperalgesia in mice by activation of TRPV1 receptors’ J Pain, vol. 14, no. 12, pp. 1629-41. https://doi.org/10.1016/j.jpain.2013.07.021

Davidson, S, Zhang, X, Khasabov, SG, Moser, HR, Honda, CN, Simone, DA & Giesler, GJ 2012, ‘Pruriceptive spinothalamic tract neurons: physiological properties and projection targets in the primate’ J Neurophysiol, vol. 108, no. 6, pp. 1711-23. https://doi.org/10.1152/jn.00206.2012

Waataja, JJ, Tweden, KS & Honda, CN 2011, ‘Effects of high-frequency alternating current on axonal conduction through the vagus nerve’ J Neural Eng, vol. 8, no. 5, pp.056013. https://doi.org/10.1088/1741-2560/8/5/056013

Schramm, CL & Honda, CN 2010, ‘Co-administration of ?- and ?-opioid receptor agonists promotes peripheral opioid receptor function’ Pain, vol. 151, no. 3, pp. 763-70. https://doi.org/10.1016/j.pain.2010.09.009

Riedl, MS, Braun, PD, Kitto, KF, Roiko, SA, Anderson, LB, Honda, CN, Fairbanks, CA & Vulchanova, L 2009, ‘Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing’ J Neurosci, vol. 29, no. 42, pp. 13377-88. https://doi.org/10.1523/JNEUROSCI.1127-09.2009

Wenk, HN, Brederson, JD & Honda, CN 2006, ‘Morphine directly inhibits nociceptors in inflamed skin’ J Neurophysiol, vol. 95, no. 4, pp. 2083-97. https://doi.org/10.1152/jn.00394.2005

Teaching

Courses

NSCI 8221: Neurobiology of Pain and Analgesia (Fall semester).