Marilyn Carroll, PhD
Professor, Department of Psychiatry
Professor, Department of Psychiatry
My research is directed toward developing behavioral and pharmacological methods of reducing and preventing drug abuse. Animals are trained to self-administer drugs that humans abuse, and several phases of the addiction process are modeled, such as acquisition, maintenance, withdrawal, craving, and relapse. Our laboratory tests a number of therapeutic drugs, such as antidepressants and opioid and dopamine agonists and antagonists; they have shown considerable efficacy in reducing drug self-administration. Behavioral methods that are proving effective are enriching the environment with alternative nondrug reinforcers; for example, food and sweet-tasting drinking solutions. Behavioral economic analyses quantify the reinforcing efficacy of the drug under varied environmental and pharmacological treatments. Recent work shows that the greatest reduction in drug self-administration is achieved when behavioral and pharmacological treatments are combined. We are also interested in the interrelationships of feeding and drug abuse, and in testing the notion of common reward mechanisms for drugs, food, and other nondrug substances and events.
Another topic of study in our laboratory is the dependence producing effect of drugs. We have found that sensitive behavioral performance measures reveal subtle behavioral deficits due to drug withdrawal when no physical signs are present. Further, these behavioral deficits last for long periods of time, and may be a factor contributing to relapse to drug abuse in humans. Behavioral disturbances have been measured after low drug doses and short or intermittent periods of access with drugs such as caffeine, nicotine, cocaine, and phencyclidine (PCP), dispelling the common notion that excessive or long term drug abuse is necessary to produce withdrawal effects. We are using this model to find pharmacological and behavioral strategies to relieve withdrawal distress.
Tosun, NL, Allen, SS, Eberly, LE, Yao, M, Stoops, WW, Strickland, JC, Harrison, KA, al Absi, M & Carroll, ME 2018, 'Association of exercise with smoking-related symptomatology, smoking behavior and impulsivity in men and women' Drug and alcohol dependence, vol. 192, pp. 29-37. https://doi.org/10.1016/j.drugalcdep.2018.07.022
Swalve, N, Smethells, JR, Younk, R, Mitchell, J, Dougen, B & Carroll, ME 2018, 'Sex-specific attenuation of impulsive action by progesterone in a go/no-go task for cocaine in rats' Psychopharmacology, vol. 235, no. 1, pp. 135-143. https://doi.org/10.1007/s00213-017-4750-2
Carroll, ME & Lynch, WJ 2016, 'How to study sex differences in addiction using animal models' Addiction Biology, vol. 21, no. 5, pp. 1007-1029. https://doi.org/10.1111/adb.12400
Martinez, LA, Gross, KS, Himmler, BT, Emmitt, NL, Peterson, BM, Zlebnik, NE, Foster Olive, M, Carroll, ME, Meisel, RL & Mermelstein, PG 2016, 'Estradiol facilitation of cocaine Self-Administration in female rats requires activation of mglur5' eNeuro, vol. 3, no. 5, e0140-16.2016. https://doi.org/10.1523/ENEURO.0140-16.2016
Swalve, N, Smethells, JR & Carroll, ME 2016, 'Progesterone attenuates impulsive action in a Go/No-Go task for sucrose pellets in female and male rats' Hormones and Behavior, vol. 85, pp. 43-47. https://doi.org/10.1016/j.yhbeh.2016.08.001
Smethells, JR, Swalve, NL, Eberly, LE & Carroll, ME 2016, 'Sex differences in the reduction of impulsive choice (delay discounting) for cocaine in rats with atomoxetine and progesterone' Psychopharmacology, vol. 233, no. 15-16, pp. 2999-3008. https://doi.org/10.1007/s00213-016-4345-3
Swalve, NL, Smethells, JR & Carroll, ME 2016, 'Sex differences in attenuation of nicotine reinstatement after individual and combined treatments of progesterone and varenicline' Behavioural Brain Research, vol. 308, pp. 46-52. https://doi.org/10.1016/j.bbr.2016.04.023
Carroll, ME, Collins, M, Kohl, EA, Johnson, S & Dougen, B 2016, 'Sex and menstrual cycle effects on chronic oral cocaine self-administration in rhesus monkeys: Effects of a nondrug alternative reward' Psychopharmacology, vol. 233, no. 15-16, pp. 2973-2984. https://doi.org/10.1007/s00213-016-4343-5
Smethells, JR, Zlebnik, NE, Miller, DK, Will, MJ, Booth, F & Carroll, ME 2016, 'Cocaine self-administration and reinstatement in female rats selectively bred for high and low voluntary running' Drug and alcohol dependence, vol. 167, pp. 163-168. https://doi.org/10.1016/j.drugalcdep.2016.08.020
Swalve, NL, Smethells, JR, Zlebnik, NE & Carroll, ME 2016, 'Sex differences in reinstatement of cocaine-seeking with combination treatments of progesterone and atomoxetine' Pharmacology Biochemistry and Behavior, vol. 145, pp. 17-23. https://doi.org/10.1016/j.pbb.2016.03.008