S. Hossein Fatemi, MD, PhD

Professor, Department of Psychiatry

S. Hossein Fatemi

Contact Info

fatem002@umn.edu

Office Phone 612-626-3633

Office Address:
392 MMC

Administrative Assistant Name
Lois Laitinen

Administrative Phone
612-273-9803

Administrative Email
laiti001@umn.edu

Administrative Fax Number
612-273-9779

MD, Case Western Reserve University

Residency, Psychiatry, University Hospitals, Cleveland, OH

PhD, Anatomy, University of Nebraska Medical Center

MS, Anatomy, University of Nebraska Medical Center

BS, Biology, Baylor University

Internship, Diagnostic Radiology at University of Cincinnati Hospital, 1991-1992

Summary

Dr. Fatemi is a Professor of Psychiatry and Neuroscience and the Bernstein Endowed Chair in Adult Psychiatry at the University of Minnesota Medical School. Dr. Fatemi’s research has focused on the biological basis of neurodevelopmental disorders, primarily autism and schizophrenia. His clinical interest has focused on the treatment of schizophrenia, bipolar disorder, and major depression. He has over 20 years of experience in research and treatment of major psychiatric disorders. Dr. Fatemi is an Elected Fellow of the American College of Psychiatrists, an Elected Fellow of the American College of Neuropsychopharmacology, and a Fellow of the Collegium Internationale Neuropsychopharmacologicum.

Professional Associations

  • Associate Chair for Neuroscience and Translational Research

Research

Research Summary/Interests

Dr. Fatemi's research focuses on the neurodevelopmental mechanisms that contribute to normal structure and function of the brain and which, under certain circumstances, cause neuropsychiatric disorders. His research has been conducted on two levels: one at the level of human brain dysfunction (postmortem studies involving schizophrenic, depressed, bipolar, and autistic patients) and secondly on development of an animal model to mimic schizophrenia and autism (prenatal viral infection in mice). Dr. Fatemi has also investigated the effects of various psychotropic agents, e.g., olanzapine, clozapine, fluoxetine, valproic acid, haloperidol, and lithium, on expression of genes of interest in rats following chronic administration of each drug. The ultimate goals of Dr. Fatemi’s research are to better understand the genesis of these disabling disorders and to treat patients afflicted by them. Dr. Fatemi’s research has been funded by multiple grants from the National Institutes of Health, the Stanley Medical Research Institute, the National Alliance for Research in Schizophrenia and Depression, and the Minnesota Medical Foundation. His research has been published in top journals including Molecular Psychiatry, Synapse, Molecular Autism, and Translational Psychiatry. Dr. Fatemi has published 121 articles, 33 book chapters, and edited five books. Dr. Fatemi is an Associate Editor of Cerebellum and Ataxias, a Regional Editor (USA) for Central Nervous System Agents in Medicinal Chemistry, and on the editorial boards of multiple journals including Molecular Psychiatry, PLoS One and Pharmacopsychiatry.

Publications

Folsom, TD, Higgins, L, Markowski, TW, Griffin, TJ & Fatemi, SH 2019, 'Quantitative proteomics of forebrain subcellular fractions in fragile X mental retardation 1 knockout mice following acute treatment with 2-Methyl-6-(phenylethynyl)pyridine: Relevance to developmental study of schizophrenia' Synapse, vol. 73, no. 1, e22069. https://doi.org/10.1002/syn.22069

Fatemi, SH, Folsom, TD & Thuras, PD 2017, 'GABAA and GABAB receptor dysregulation in superior frontal cortex of subjects with schizophrenia and bipolar disorder' Synapse, vol. 71, no. 7, e21973. https://doi.org/10.1002/syn.21973

Fatemi, SH, Folsom, TD & Thuras, PD 2017, 'Altered subcellular localization of fragile X mental retardation signaling partners and targets in superior frontal cortex of individuals with schizophrenia' NeuroReport, vol. 28, no. 16, pp. 1066-1070. https://doi.org/10.1097/WNR.0000000000000880

Fatemi, SH, Folsom, TD, Liesch, SB, Kneeland, RE, Karkhane Yousefi, M & Thuras, PD 2017, 'The effects of prenatal H1N1 infection at E16 on FMRP, glutamate, GABA, and reelin signaling systems in developing murine cerebellum' Journal of Neuroscience Research, vol. 95, no. 5, pp. 1110-1122. https://doi.org/10.1002/jnr.23949

Frye, RE, Casanova, MF, Fatemi, SH, Folsom, TD, Reutiman, TJ, Brown, GL, Edelson, SM, Slattery, JC & Adams, JB 2016, 'Neuropathological mechanisms of seizures in autism spectrum disorder' Frontiers in Neuroscience, vol. 10, no. MAY, 192. https://doi.org/10.3389/fnins.2016.00192

Fatemi, SH & Folsom, TD 2015, 'GABA receptor subunit distribution and FMRP-mGluR5 signaling abnormalities in the cerebellum of subjects with schizophrenia, mood disorders, and autism' Schizophrenia Research, vol. 167, no. 1-3, pp. 42-56. https://doi.org/10.1016/j.schres.2014.10.010

Folsom, TD, Thuras, PD & Fatemi, SH 2015, 'Protein expression of targets of the FMRP regulon is altered in brains of subjects with schizophrenia and mood disorders' Schizophrenia Research, vol. 165, no. 2-3, pp. 201-211. https://doi.org/10.1016/j.schres.2015.04.012

Fatemi, SH & Folsom, TD 2014, 'Existence of monomer and dimer forms of mGluR5, under reducing conditions in studies of postmortem brain in various psychiatric disorders' Schizophrenia Research, vol. 158, no. 1-3, pp. 270-271. https://doi.org/10.1016/j.schres.2014.06.029

Fatemi, SH, Reutiman, TJ, Folsom, TD, Rustan, OG, Rooney, RJ & Thuras, PD 2014, 'Downregulation of GABAA receptor protein subunits ?6, ?2, ?, ?, ?2, ?, and ?2 in superior frontal cortex of subjects with autism' Journal of Autism and Developmental Disorders, vol. 44, no. 8, pp. 1833-1845. https://doi.org/10.1007/s10803-014-2078-x

Rustan, ØG, Folsom, TD, Yousefi, MK & Fatemi, SH 2013, 'Phosphorylated fragile X mental retardation protein at serine 499, is reduced in cerebellar vermis and superior frontal cortex of subjects with autism: Implications for fragile X mental retardation protein-metabotropic glutamate receptor 5 signaling' Molecular Autism, vol. 4, no. 1, 41. https://doi.org/10.1186/2040-2392-4-41

Clinical

Board Certifications

  • Adult psychiatry, Diplomate of American Board of Psychiatry and Neurology
  • Psychosomatic medicine, Diplomate of American Board of Psychiatry and Neurology