Sabita Roy, PhD

Professor, Department of Surgery

Sabita Roy

Contact Info

royxx002@umn.edu

Office Address:
Department of Surgery
11-204 MMT Bldg
515 Delaware St SE
Minneapolis, MN 55455

Mailing Address:
Surgery BTR
MMC 195 Mayo
8195F
420 Delaware St SE
Minneapolis, MN 55455

Administrative Assistant Name
Leeanne Dongses

Administrative Phone
612-624-4581

Administrative Email
Leeanne@umn.edu

Professor, Department of Surgery

Division of Basic and Translational Research

Professor of Surgery and Pharmacology, Inflammation and Vascular Biology Division of Infection

Co-Vice Chair of Career Development and Succession Planning, Medical School

Institute for Molecular Virology

Department of Pharmacology


Director, Division of Infection, Inflammation and Vascular Biology


PhD, University of Kansa (Neurobiology), 1986

MSc, All India Institute of Human Physiology Medical Sciences, 1981

BSc, Panjab University (Biology), 1977

Post Doctoral Training - Department of Pharmacology, University of California San Francisco (UCSF); Department of Pharmacology, University of Minnesota, Minneapolis

Summary

Expertise

HIV-associated brain and GALT pathology in the context of drug abuse and opportunistic infection

Professional Associations

  • Co-Director: PharmacoNeuroImmune (PNI) Training grant-Mentoring of trainees
  • Course Director: Pharmacology of Drug Abuse (NSC 8028, PHCL 8028)
  • Co-Course Director: Neuroimmune Pharmacology (NSC 8026, PHCL 8026)

Research

Research Summary/Interests

Chronic morphine and immunosupression

- Molecular and cellular mechanism
- Consequence on wound healing events
- Susceptibility to opportunistic infection

Morphine modulation of Hypoxia induced Hif-1 alpha and consequence in angiogenesis, wound repair and intimal hyperplasia

Dr. Roy's laboratory is investigating the molecular mechanism of morphine-induced immunosuppression. Impaired immunity is a major contributing factor in the prevalence of opportunistic infections such as AIDS in chronic drug abusers. Understanding the molecular mechanism of morphine action will facilitate the development of biotherapies to overcome immunosuppression while retaining analgesic properties.

Publications

  • Kelschenbach J, Barke RA, Roy S (2008) Role of Mu opioid receptor and Corticosterone in Morphine withdrawal mediated Th2 differentiation and suppression of IL-12. JNeuroimmunol. (submitted)
  • Kelschenbach J, Ninkovic J, Wang JH, Krishnan A, Charboneau R, Barke RA, Roy S (2008) Morphine withdrawal inhibits inhibits macrophage IL-12 synthesis by modulating the cAMP signaling pathway. J Immunol. (in press)
  • Wang JH, Barke RA, Charboneau R and Roy S (2008) Morphine modulation of alveolar macrophages increases pulmonary s. pneumoniae infection. J Immunology (in press).
  • Kelschenbach J, Barke RA, Roy S (2008) Role of Innate Immunity in Morphine withdrawal. J Immunol. (under revision)
  • Wang JH, Loh HH and Roy S (2008) Differential effects of-endorphin on Mu- and Delta opioid receptor. J. Neuroscience (submitted).
  • Koodie L, Ramakrishnan S and Roy S (2008) Morphine modulates tumor angiogenesis through a HIF alpha dependent pathway. Cancer Res. (submitted).
  • Wang J, Barke RA, Roy S. (2007) Transcriptional and epigenetic regulation of IL-2 gene in activated T cells by morphine. J Biol Chem. 2007 Jan 16; [Epub ahead of print]
  • Hamilton KL, Franklin LM, Roy S, Schrott LM. (2007). Prenatal opiate exposure attenuates LPS-induced fever in adult rats: Role of interleukin-1beta. Brain Res. 2007 Feb 16;1133(1):92-9.
  • Vatassery GT. Quach HT, Smith WE., SantaCruz KS and Roy S (2008) Apolipoprotein E deficiency leads to altered brain uptake of alpha tocopherol injected into lateral cerebral ventricles. Biochimica et Biophysica Acta Molecular Basis of Disease Jul;1772(7):797-803. Epub 2007 May 3.