Jizhen Lin, MD

Associate Professor, Department of Otolaryngology, Head and Neck Surgery

Jizhen Lin

Contact Info


Mailing Address:
Lions Research Bldg.
Room 216
2001 6th Street SE
Minneapolis, MN 55455

Administrative Phone

Fujian Medical College

Union Hospital

Clinical - Union Hospital

Research - University of Minnesota


Research Summary/Interests

  • Otitis media with a focus on mucous cell metaplasia in pneumococcal otitis media.
  • Identification of cochlear neural progenitors and differentiation of them into hair cells, supporting cells and neurons in vitro.
  • Identification of head and neck cancer stem cells and determination of their role in initiating head and neck cancer.


  • Lin J, Guan Z, Wang C, Feng L, Zheng Y, Caicero E, Bearth E, Peng J, Gaffney P, Ondrey FG. Id1 Contributes to HNSCC Survival via the NF-kB/surviving and PI3K/Akt Signaling Pathways. Clin Cancer Res, 2010; 16:77-87.
  • Hu X, Huang J, Feng L, Fukudome S, Hamajima Y, Lin J. Sonic Hedgehog (SHH) promotes the differentiation of Mouse Cochlear Neural Progenitors via the Math-Bm3.1 Signaling Pathway in vitro. J Neurosci Res 2010; 88:927-35.
  • Hamajima Y, Komori M, Preciado DA, Choo DI, Moribe K, Murakami S, Ondrey FG, Lin J. The Role of Inhibitor of DNA-Binding (Id1) in Hyperproliferation of Keratinocytes: The Pathological Basis for Middle Ear Cholesteatoma Derived from Chronic Otitis Media. Cell Proliferation, 2010. 43:457-463.
  • Hamajima Y, Komori M, Preciado DA, Choo DI, Moribe K, Murakami S, Ondrey FG, Lin J: Id1 induces the proliferation of keratinocytes and expression of keratin 10: the pathological basis for cholesteatoma. 2008; J Assoc Res Otolaryngol, revised.
  • Ozeki M, Hamajima Y, Feng L, Ondrey FG, Schlentz EP, Lin J: Id1 induces the proliferation of cochlear sensorineural epithelial cells via the nuclear factor kappa B/cyclin D1 pathway in vitro. J Neurosci Res 2007. 85:515-524.
  • Lin J, Tsuboi Y, Rimell F, Liu G, Toyama K, Kawano H, Paparella MM, Ho SB: Expression of mucins in Mucoid Otitis Media. J Assoc Res Otolaryngol 2003; 4:384-393.