Matthew Wheelwright

Matthew Wheelwright

Email: wheel381@umn.edu

Entering Class:
 2011

Education:

University of California, Los Angeles
Neuroscience major, Near Eastern Languages and Culture minor
B.S., 2010

University of Minnesota
Integrative Biology and Physiology Graduate Program
Ph.D., 2017

Honors and Awards:

  • Warwick MD/PhD Student Fellowship, 2013-2014

MSTP Student Governance:

  • Student Advisory Committee 2012-2014
  • Student Admissions Committee, 2013, 2014
  • Retreat Planning Committee 2013

Thesis Advisor: Joseph Metzger, Ph.D.

Research Interests

Molecular Cardiology

Publications

Wheelwright M, Win Z, Mikkila JL, Amen KY, Alford PW, Metzger JM. Investigation of human iPSC-derived cardiac myocyte functional maturation by single cell traction force microscopy. PLoS One. 2018 Apr 4;13(4):e0194909.

Bedada FB, Wheelwright M, Metzger JM. Maturation status of sarcomere structure and function in human iPSC-derived cardiac myocytes. Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1829-38 Review. PMCID: PMC4864165

For work prior to entering the MSTP:

Wheelwright M, Kim EW, Inkeles MS, De Leon A, Pellegrini M, Krutzik SR, Liu PT. All-trans retinoic acid-triggered antimicrobial activity against Mycobacterium tuberculosis is dependent on NPC2. J Immunol. 2014 Mar 1;192(5):2280-90. PMCID: PMC3954114.

Liu PT, Wheelwright M, Teles R, Komisopoulou E, Edfeldt K, Ferguson B, Mehta MD, Vazirnia A, Rea TH, Sarno EN, Graeber TG, Modlin RL. MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy. Nat Med. 2012 Jan 29;18(2):267-73. PMCID: PMC3274599.

Edfeldt K, Liu PT, Chun R, Fabri M, Schenk M, Wheelwright M, Keegan C, Krutzik SR, Adams JS, Hewison M, Modlin RL. T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism. Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22593-8. PMCID: PMC3012480.

Liu PT, Schenk M, Walker VP, Dempsey PW, Kanchanapoomi M, Wheelwright M, Vazirnia A, Zhang X, Steinmeyer A, Zügel U, Hollis BW, Cheng G, Modlin RL. Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses. PLoS One. 2009 Jun 5;4(6):e5810. PMCID: PMC2686169.