Nathan E. Welty

Nathan WeltyEmail: welt0123@umn.edu

Entering Class:
2008

Education:

Westmont College
Chemistry and English majors
B.S., 2008

University of Minnesota
Microbiology, Immunology and Cancer Biology
Ph.D., 2014

Honors and Awards:

  • Ruth L. Kirschstein National Research Service Award for Predoctoral MD/PhD Fellows, National Institute of Diabetes and Digestive and Kidney Diseases, 2013-2018
  • University of Minnesota Foundation J. Jacob Kaplan Award, 2014
  • Warren and Henrietta Warwick Fellowship, 2012
  • Medical School Honors, Years 1 and 2

MSTP Student Governance:

  • Student Advisory Committee 2013-15

Thesis Advisor: Dan Kaplan, M.D., Ph.D.

Thesis Research

The balance of intestinal immunity and tolerance is key in infection and autoimmunity, as well as in homeostatic responses to ingested antigen and commensal microbes. Lamina propria dendritic cells (lpDC) are antigen-presenting cells that reside below the intestinal epithelium and initiate adaptive immune responses to regulate this balance. There are several distinct subsets of lpDC, however the *in vivo* function of these subsets remains to be elucidated. Using transgenic mice in which we specifically target these subsets for deletion or genetic modification, my research aims to understand the subset-specific functions of lpDC in maintaining steady-state tolerance and in promoting immunity to pathogens.

Publications (pubmed)

Welty NE, Staley C, Ghilardi N, Sadowsky MJ, Igyártó BZ, Kaplan DH. Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism. J Exp Med. 2013 Sep 23;210(10):2011-24. PMCID: PMC3782055

Publications prior to entering the MD/PhD Program:

Iles KE, Wright MM, Cole MP, Welty NE, Ware LB, Matthay MA, Schopfer FJ, Baker PRS, Agarwal A, Freeman BA. Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway. Free Radic Biol Med. 2009;46:866-875. PMCID: PMC3104854

Iles KE, Dickinson DA, Wigley AF, Welty NE, Blank V and Forman HJ. HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells. Free Radic Biol Med. 2005;39:355-364. PMCID: PMC2798573