Chen Lab

The Chen Clinical Research Lab is focused on patient-oriented research related to atrial fibrillation and atrial myopathy with particular emphasis on 3 themes:

(1) To identify novel risk factors for atrial fibrillation and atrial myopathy, and discover new strategies to prevent both conditions,

(2) To characterize the relationship of atrial fibrillation and atrial myopathy to cardiovascular and neurocognitive outcomes such as stroke and dementia, and to elucidate the underlying mechanisms,

(3) To discover novel strategies to prevent complications related to atrial fibrillation and atrial myopathy

Lin Yee Chen, MD, MS faculty bio

Current Projects

NIH RF1 NS135615 (2023-2028): Cognitive Impairment and Dementia, Vascular Brain Injury, and Atrial Myopathy: Implications for Prevention of Alzheimer's Disease-Related Dementias
NIH RF1 NS127266 (2022-2027), Cognitive Aging, Brain Morphology, and Arrhythmias in Hispanics/Latinos: Implications for Prevention and Management of Alzheimer's Disease-Related Dementias
NIH R01 AG075883 (2022-2027), Novel application of Digital signals of movement, sleep and heart rhythms for detection of Alzheimer's Disease and Related Dementias
NIH R01 HL158022 (2022-2026), Glucose patterns and cardiac arrhythmias in older adults with diabetes
NIH K24 HL155813 (2021-2026): Mentoring and Research to Classify Atrial Cardiomyopathy
NIH R01 HL141288 (2018-2023): Left Atrial Abnormality and Atrial Fibrillation-Related Cerebral Infarcts and Cognitive Decline
NIH R01 HL126637 (2016-2023): Significance of Atrial Fibrillation and Atrial Fibrillation Burden Detected by Novel ECG Monitoring in Community-Dwelling Elderly

Selected Publications

Maheshwari A, Norby FL, Inciardi RM, Wang W, Zhang MJ, Soliman EZ, Alonso A, Johansen MC, Gottesman RF, Solomon SD, Shah AM, Chen LY. Left Atrial Mechanical Dysfunction and the Risk for Ischemic Stroke in People Without Prevalent Atrial Fibrillation or Stroke: A Prospective Cohort Study. Ann Intern Med 2022. doi: 10.7326/M22-1638.

Wang W, Zhang MJ, Inciardi RM, Norby FL, Johansen MC, Parikh R, Van’t Hof JR, Alonso A, Soliman EZ, Mosley TH, Gottesman RF, Shah AM, Solomon SD, Chen LY. Association of Echocardiographic Measures of Left Atrial Function and Size With Incident Dementia. JAMA 2022;327(12):1138-1148.

Chen LY, Ribeiro ALP, Platonov PG, Cygankiewicz I, Soliman EZ, Gorenek B, Ikeda T, Vassilikos VP, Steinberg JS, Varma N, Bayes-de-Luna A, Baranchuk A. P Wave Parameters and Indices: A Critical Appraisal of Clinical Utility, Challenges, and Future Research—A Consensus Document Endorsed by the International Society of Electrocardiology and the International Society for Holter and Noninvasive Electrocardiology. Circ Arrhythm Electrophysiol. 2022;15:e010435.

Johansen MC, Wang W, Zhang MJ, Alonso A, Wong DF, Gottesman RF, Chen LY. Associations between atrial arrhythmias and brain amyloid deposition: The ARIC-PET Study. J Alzheimers Dis. 2022;86(1):43-48

Rooney MR, Norby FL,Maheshwari A, Lutsey PL, Dudley SC, Soliman EZ, Loehr LR, Mosley TH, Coresh J, Alonso A, Chen LY. Frequent Premature Atrial Contractions are Associated with Poorer Cognitive Function: the Atherosclerosis Risk in Communities (ARIC) Study. Mayo Clin Proc. 2021;96(5):1147-1156.

Harding BN, Norby FL, Heckbert SR, McKnight B, Psaty BM, Floyd JS, Chen LY. Longitudinal measures of blood pressure and subclinical atrial arrhythmias: The Multi-Ethnic Study of Atherosclerosis and the Atherosclerosis Risk in Communities Study. J Am Heart Assoc 2021;10(11):e020260.

Wang W, Norby FL, Zhang MJ, Reyes, JL, Shah AM, Soliman EZ, Lutsey PL, Alonso A, Solomon SD, Inciardi RM, Chen LY. Differences in Left Atrial Size and Function and Supraventricular Ectopy between Black and White Participants in the Atherosclerosis Risk in Communities (ARIC) Study: Implications for Atrial Fibrillation Risk. J Am Heart Assoc 2021 10(21):e021723.

Maheshwari A, Norby FL, Soliman EZ, Alonso A, Sotoodehnia N, Chen LY. Association of P-Wave Abnormalities with Sudden Cardiac and Cardiovascular Death: The Atherosclerosis Risk (ARIC) in Communities Study. Circ Arrhythm Electrophysiol 2021;14(2):e009314.

Kim ED, Soliman EZ, Coresh J, Matsushita K, Chen LY. Two-week burden of arrhythmias across chronic kidney disease severity in a large community-based cohort: The ARIC Study. J of American Society of Nephrology 2021;32(3): 629-638.

Norby FL, Alonso A, Rooney MR, Maheshwari A, Koene RJ, Zhang MJ, Soliman EZ, Loehr LR, Mosley TH, Gottesman RF, Coresh J, Chen LY. Association of Ventricular Arrhythmias with Dementia: The Atherosclerosis Risk in Communities (ARIC) Study. Neurology 2021;96(6):e926-e936.

Maheshwari A, Norby FL, Roetker NS, Soliman EZ, Koene RJ, Rooney MR, O’Neal WT, Shah AM, Claggett BL, Solomon SD, Alonso A, Gottesman RF, Heckbert SR, Chen LY. Refining Prediction of Atrial Fibrillation-Related Stroke Using the P2-CHA2DS2-VASc Score: the Atherosclerosis Risk in Communities (ARIC) study and Multi-Ethnic Study of Atherosclerosis (MESA). Circulation 2019;139(2):180-191.

Current Members