Mouse Behavior Core

The goal of the Mouse Behavior Core is to provide the highest quality assessment of the neurological status and specific behaviors in mice for investigators who use murine models to address questions about basic biology or disease in the CNS.

Our facility was established to consolidate, centralize and standardize mouse behavioral testing in order to lower the barriers to integrating behavioral studies, foster innovation, and facilitate collaboration. The Core Director is Dr. Michael Benneyworth.

The Core provides consultation of project design, test selection and data analysis, access to and training on behavioral equipment, and full-service testing performed by experienced core staff.  Following an initial consultation, a PI may decide to have testing performed by dedicated, experienced Core staff or to have members of the investigator’s own lab trained to run the tests of interest.

Currently, we offer support for running a wide range of tests including assays of neuromotor function (e.g. activity, coordination and gait analysis), affective behavior (anxiety, depression, addiction), and cognition (reference and working memory, instrumental and spatial navigation tasks). With two sites (Wallin Medical Bioscience Building and Jackson Hall), there are ample and highly accessible opportunities for researchers to utilize core resources to expand the scope of their investigations.

Publications

Papers from our Core

Martin-Fernandez M, Jamison S, Robin LM, Zhao Z, Martin ED, Aguilar J, Benneyworth MA, Marsicano G, Araque A (2017) Synapse-specific astrocyte gating of amygdala-related behavior. Nat Neurosci. 2017 Sep 25. doi: 10.1038/nn.4649. [Epub ahead of print] PMID: 28945222

Laoharawee K, Podetz-Pedersen KM, Nguyen TT, Evenstar LB, Kitto KF, Nan Z, Fairbanks CA, Low WC, Kozarsky KF, McIvor RS. (2017) Prevention of Neurocognitive Deficiency in Mucopolysaccharidosis Type II Mice By CNS-Directed, AAV9-Mediated Iduronate Sulfatase Gene Transfer. Hum Gene Ther. [Epub ahead of print] PMID: 28478695

Belur LR, Temme A, Podetz-Pedersen KM, Riedl M, Vulchanova L, Robinson N, Hanson LR, Kozarsky KF, Orchard PJ, Frey Ii WH, Low WC, McIvor RS. (2017) Intranasal Adeno-Associated Virus Mediated Gene Delivery and Expression of Human Iduronidase in the Central Nervous System: A Noninvasive and Effective Approach for Prevention of Neurologic Disease in Mucopolysaccharidosis Type I. Hum Gene Ther. [Epub ahead of print] PMID:2846259

Kennedy BC, Dimova JG, Dakoji S, Yuan LL, Gewirtz JC, Tran PV. (2016) Deletion of Novel Protein TMEM35 Alters Stress-related Functions and Impairs Long-term Memory in Mice. Am J Physiol Regul Integr Comp Physiol. 311(1):R166-78 PMID:27170659

Victoria NC, Marron Fernandez de Velasco E, Ostrovskaya O, Metzger S, Xia Z, Kotecki L, Benneyworth MA, Zink AN, Martemyanov KA, Wickman K. (2015) G Protein-Gated K+ Channel Ablation in Forebrain Pyramidal Neurons Selectively Impairs Fear Learning. Biol Psychiatry. 2015 Nov 10. PMID: 26612516

McBrayer ZL, Dimova J, Pisansky MT, Sun M, Beppu H, Gewirtz JC, O'Connor MB (2015) Forebrain-Specific Loss of BMPRII in Mice Reduces Anxiety and Increases Object Exploration. PLoS One. Oct 7;10 PMID:26444546

Wydeven N, Fernandez de Velasco EM, Du Y, Benneyworth MA, Hearing MC, Fischer RA, Thomas MJ, Weaver CD, Wickman K (2014) Mechanisms underlying the activation of G-protein–gated inwardly rectifying K+ (GIRK) channels by the novel anxiolytic drug, ML297 Proc Natl Acad Sci U S A. 111(29): 10755–10760. PMCID: PMC4115558

Le Naour M, Lunzer MM, Powers MD, Kalyuzhny AE, Benneyworth MA, Thomas MJ, Portoghese PS (2014) KOR opioid heteromers as targets for developing analgesics free of adverse effects. J Med Chem. 57(15):6383-92. PMCID: PMC4136663