Colin R. Campbell, PhD

Associate Professor, Department of Pharmacology

Colin R. Campbell

Contact Info

campb034@umn.edu

Office Phone 612-625-8986

Office Address:
NHH 3-130

Associate Professor, Department of Pharmacology

Director of Graduate Studies, Department of Pharmacology

Assistant Dean for Graduate Education, Medical School


PhD, Boston University

Research

Research Summary/Interests

Cancer-fighting drugs that exert their action through the destruction of cellular DNA represent mainstays in the treatment of this disease. While the development of these drugs has led to clear progress in our ability to treat cancer, long-term survival rates still remain unacceptably low. One reason for this is the emergence following cancer chemotherapy of drug-resistant tumors. Many of these drug-resistant cancers have acquired the ability to repair DNA damage caused by the chemotherapeutic agents. Evidence generated in Dr. Campbell's laboratory strongly suggests that one mechanism of cancer cell drug resistance involves elevated levels of recombinational DNA repair.

The focus of Dr. Campbell's laboratory is to gain a greater understanding of molecular genetic mechanisms of DNA repair and recombination in mammalian cancer cells. Their goal is to identify genes that play important roles in this process, and to determine how their protein products catalyze DNA repair in these cells. The long-term objective of their efforts is to identify targets for future therapeutic intervention, in order to increase the effectiveness of cancer treatment. They use gene transfer and cloning strategies, as well as traditional biochemical approaches to achieve these goals.

Publications