Ashley T. Haase, MD

Regents' Professor and Head, Department of Microbiology and Immunology ;
Professor of Medicine (Joint Appointment) Infectious Diseases and Internal Medicine,

Ashley T. Haase

Contact Info

haase001@umn.edu

Office Address:
2-115 MRF
689 23rd Ave SE
Minneapolis, MN 55455

Mailing Address:
Department of Microbiology & Immunology
2-115 MRF
CDC: 2821A
689 23rd Ave SE
Minneapolis, MN 55455

Regents' Professor and Head, Department of Microbiology and Immunology ;
Professor of Medicine (Joint Appointment) Infectious Diseases and Internal Medicine

MICaB Graduate Program, Microbiology, Immunology and Cancer Biology (MICaB) Ph.D. Graduate Program

Molecular Virology, Institute for Molecular Virology


MD, Columbia College of Physicians and Surgeons, 1965

Summary

Ashley T. Haase is a Regents' Professor and Head of the Department Microbiology and Immunology at the University of Minnesota, Minneapolis. Dr. Haase has devoted the past 25 years of his career to investigating human (HIV-1/AIDS) and non-human primate (SIV) lentivirus infections, and his laboratory is currently investigating the globally predominant sexual route of HIV transmission in the SIV rhesus macaque model with the goal of developing effective vaccines and microbicides. Dr. Haase is an NIH NINDS Javits Awardee and two-time recipient of an NIH MERIT Award for his work on HIV, and a member of the Institute of Medicine of the National Academy of Sciences.

Research

Research Summary/Interests

Viral pathogenesis, HIV

My laboratory investigates the pathogenesis, treatment and prevention of lentiviral immunodeficiency infections caused by HIV-1 and its simian relative, SIV, using such technologies as in situ hybridization, in situ tetramer staining and quantitative image analysis to visualize infection and the hosts’ cellular immune response in tissues. Much of our recent work has focused on sexual mucosal transmission and the acute stage of SIV infection, the roles of “resting” and activated CD4 T cells in establishing infection, and the mechanisms of the massive depletion of CD4 T cells in the gut. Going forward, these studies provide a foundation for studies of the correlates of protection for attenuated vaccines, and the development of vaccines and microbicides to prevent transmission. My laboratory has also undertaken a comprehensive microarray analysis of HIV-1 and SIV infections with the objectives of understanding pathogenesis and identifying novel targets for treatment and prevention. Current efforts focus on broadening the microarray analysis to encompass the early through late stages of HIV-1 infection, and mapping genes identified in the analysis to gain insight into their function in HIV-1 infected lymphatic tissues, the principal sites of virus production, persistence and pathology.

Publications

  • Shang, L., A. Smith, L. Duan, K. Perkey, S. Wietgrefe, M. Zupancic, P.J. Southern, R.P. Johnson, J.V. Carlis, and A.T. Haase. 2018. Vaccine-associated maintenance of epithelial integrity correlated with protection against virus entry. J. Infect. Dis. 218(8): 1272-1283.
  • Shang, L., A.J. Smith, C.S. Reilly, L. Duan, K.E. Perkey, S. Wietgrefe, M. Zupancic, P.J. Southern, R.P. Johnson, J.V. Carlis, and A.T. Haase. 2018. Vaccine-modified NF-kB and GR signalling in cervicovaginal epithelium correlates with protection. Mucosal Immunol. 11(2):512-522.
  • Estes, J.D., C. Kityo, F. Ssali, L. Swainson, K. Nganou Makamdop, G.Q. Del Prete, S.G. Deeks, P. Luciw, J. Chipman, G. Beilman, T. Hoskuldsson, A. Khoruts, J. Anderson, C. Deleage, J. Jasurda, T. Schmidt, M. Hafertepe, S. Callisto, H. Pearson, T. Reimann, J. Schuster, J. Schoephoerster, P. Southern, K. Perkey, L. Shang, S. Wietgrefe, C.V. Fletcher, J.D. Lifson, D.C. Douek, J.M.McCune, A. T. Haase, and T. W. Schacker. 2017. Defining total-body AIDS-virus burden with implications for curative strategies. Nature Med. 23: 1271-1276.
  • Voss, J.E., M.S. Macauley, K.A. Rogers, F. Villinger, L. Duan, L. Shang, E.A. Fink, R. Andrabi, A.D. Colantonio, J.E. Robinson, R.P. Johnson, D.R. Burton, and A.T. Haase. 2016. Reproducing SIV?nef vaccine correlates of protection: trimeric gp41 antibody concentrated at mucosal front lines. AIDS 30(16): 2427-2438.
  • Shang, L., L. Duan, K.E. Perkey, S. Wietgrefe, M. Zupancic, A.J. Smith, R.P. Johnson, and A.T. Haase. 2016. Epithelium-innate immune cell axis in mucosal resonses to SIV. Mucosal Immunol. 10: 508-519.
  • Zeng, M., A. Smith, L. Shang, S.W. Wietgrefe, J. Voss, J.V. Carlis, Q. Li, M. Piatak, Jr., J.D. Lifson, R.P. Johnson, and A.T. Haase. 2016. Mucosal humoral immune response to SIVmac239?nef vaccination and vaginal challenge. J. Immunol. 196: 2809-2818.
  • Smith, A.J., S.W. Wietgrefe, L. Shang, C.S. Reilly, P.J. Southern, K.E. Perkey, L. Duan, H. Kohler, S. Müller, J. Robinson, J.V. Carlis, Q. Li, R.P. Johnson, and A.T. Haase. 2014. Live SIV vaccine correlation of protection: immune complex-inhibitory Fc receptor interactions that reduce target cell availability. J. Immunol. 193: 3126-3133.
  • Li, Q., M. Zeng, L. Duan, J. E. Voss, A.J. Smith, S. Pambuccian, L. Shang, S. Wietgrefe, P.J. Southern, C.S. Reilly, P.J. Skinner, M.L. Zupancic, J.V. Carlis, M. Piatak, Jr., D. Waterman, R.K. Reeves, K. Masek-Hammerman, C.A. Derdeyn, M.D. Alpert, D.T. Evans, H. Kohler, S. Müller, J. Robinson, J.D. Lifson, D.R. Burton, R.P. Johnson, and A.T. Haase. 2014. Live SIV vaccine correlate of protection: local antibody production and concentration on the path of virus entry. J. Immunol. 193: 3113-3125.
  • Shang, L., A.J. Smith, L. Duan, K.E. Perkey, L. Qu, S. Wietgrefe, M. Zupancic, P.J. Southern, K. Masek-Hammerman, R.K. Reeves, R.P. Johnson, and A.T. Haase. 2014. NK cell responses to SIV vaginal exposure in naïve and vaccinated rhesus macaques. J. Immunol. 193: 277-284.